Bay Area storms: Another round of ‘dangerous’ wind, rain expected to hit region

Another windy deluge could send some streams over their banks and cause widespread power outages across the Bay Area over the next couple days, marking the latest salvo from an ongoing parade of winter storms that shows no sign of relenting any time soon.

The latest atmospheric river-fed storm is expected to pack damaging winds and drop several more inches of rain over much of the Bay Area — a double-whammy that forecasters say should peak Monday morning and linger through Tuesday. Even more storms are forecast to make landfall beginning later this week — threatening to further saturate soils during one of the Bay Area’s most waterlogged stretches in recent years.

On Sunday afternoon, Gov. Gavin Newsom implored Californians to avoid driving through flooded roadways and to prepare for even more water in the near future — noting that 12 people had died over the last week and a half due to storms across the state.

“Use your common sense,” Newsom said at a press conference. “Don’t test fate… just a foot of water and your car’s floating. So it’s really important that people are mindful, and again, just use their common sense.”

The National Weather Service issued a flood warning for areas along the Guadalupe River above the Almaden Expressway in San Jose. The river is expected to reach its flood state of 9.5 feet by 9 a.m. Monday before cresting at 11.5 feet at about 4 p.m. that day.

Juan Alexander takes a picture of Belen Cortez, as they stop at the Penitencia Creek. The creek has a strong flow during a break in the rain in San Jose, Calif., on Sunday, Jan. 8, 2023. (Josie Lepe for Bay Area News Group)
Juan Alexander takes a picture of Belen Cortez, as they stop at the Penitencia Creek. The creek has a strong flow during a break in the rain in San Jose, Calif., on Sunday, Jan. 8, 2023. (Josie Lepe for Bay Area News Group) 

A flood watch also exists through Tuesday for almost the entire Bay Area. Alameda Creek near Niles Canyon and Sunol could reach its flood stage of 9 feet on Monday morning before cresting that afternoon, just shy of its 14-foot, 9-inch record. Also at risk of topping their banks were Arroyo de la Laguna at Verona in Alameda County and the San Lorenzo River in Santa Cruz County.

On Sunday afternoon, Santa Clara County officials issued evacuation warnings — essentially, advisements to be prepared to leave a moment’s notice — to people living in the watershed areas of the Uvas Reservoir and Pacheco Pass River Basin, due to flooding concerns. The warnings are impacting roughly 1,600 people, according to the county.

“This is going to be dangerous,” said Brayden Murdock, a National Weather Service meteorologist.

Updated forecast rainfall totals for round 2, expected to begin tonight between 10 pm and midnight. The heaviest rain will occur between 4 am and 4 pm Monday. Slight lowering of totals from the Bay Area northward and southern valleys. More details in follow up tweet.#CAwx


— NWS Bay Area 🌉 (@NWSBayArea) January 8, 2023

Standing under a break in the clouds on Sunday in San Francisco’s Potrero Hill neighborhood, Becky Luong expressed fatigue at the unrelenting pace of storms. Her home’s garage in the Portola neighborhood was flooded with about an inch of water during Wednesday’s storm — ruining several pairs of shoes stored down there and leaving damaged a few bags of concrete.

“I’ve never experienced such a big storm like this,” said Luong, who has lived in the city for close to three decades. “It is the wind that makes it worse. This is different. I got scared.”

“I’m tired,” she added, about the recent wet weather. “I’m so grateful to see the sun today.”

Nearby, Nick Bulley waited in line for workers to fill his car with sandbags to protect his house in the hilly Twin Peaks neighborhood. The backyard and first floor of his newly renovated home were flooded during the New Year’s Eve storm with an inch of water, likely causing thousands of dollars in damage. On Sunday, he ran a dehumidifier to suck up all the moisture and limit the cost of repairs.

“This was just an unusual event,” Bulley said. “We weren’t prepared. We didn’t have sandbags. Now we’re making sure we have something to at least toss in front of the doors.”

The heaviest downpours should begin to subside by midday Monday, Murdock said, though chances for additional precipitation should linger through Tuesday. Most of the Bay Area — including San Francisco and Oakland — could see 2 to 3 inches of rain by Tuesday, the weather service said. San Jose is expected to see a little more than 2 inches from this storm.

A PG&E employee works on damaged utility lines along Sandy Road on Sunday, Jan. 8, 2023, in Castro Valley, Calif. A large eucalyptus tree fell Saturday afternoon severely damaging a home, trapping a person inside and knocking down utility lines. (Aric Crabb/Bay Area News Group)
A PG&E employee works on damaged utility lines along Sandy Road on Sunday, Jan. 8, 2023, in Castro Valley, Calif. A large eucalyptus tree fell Saturday afternoon severely damaging a home, trapping a person inside and knocking down utility lines. (Aric Crabb/Bay Area News Group) 

The heaviest rainfall should fall over the waterlogged Santa Cruz Mountains, where 5 to 7 inches of rain is expected, with a few places seeing as much as 8 inches. To the south, the Santa Lucia Mountains along the Big Sur coast could see 8 to 12 inches of rain in some spots.

In addition, howling winds could once again raise the risk of power outages from trees falling onto power lines.

Winds of 25 to 35 mph are expected across much of the Bay Area’s lower-lying regions, with gusts potentially hitting 60 mph, the National Weather Service said while issuing a high wind warning. Along the coast and the Bay Area’s peaks, forecasters are expecting winds of 35 to 50 mph and gusts of up to 80 mph.

“This is also going to be a wind event,” said Murdock, adding that “when you do have strong winds after seeing plenty of moisture in the soil, you can see trees fall.”

The storm marks the latest atmospheric river to drench Northern California over the last couple of weeks, whipsawing the region from one of its driest three-year runs in recorded history to a state of perpetual flood risk. Oakland, for example, has received 15.84 inches of rain since Dec. 1 — almost all of it in the last two weeks. That’s more than two-thirds of the 22.89 inches of rain it normally gets in a calendar year.

Still, even though the recent wet weather has begun to alleviate drought conditions across Northern California, experts say even more moisture is needed to put an end the region’s historic drought. Water levels at some of the state’s largest reservoirs — including Lake Shasta, Lake Oroville and Trinity Lake — remain below historical averages for this time of year, even though some have started to tick upward in recent weeks.

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Verstappen wil niet in de film met Hamilton, Australië kent maar liefst vier DRS-zones l GPFans News

Max Verstappen heeft de laatste jaren flink aan populariteit gewonnen in de wereld. Met name tijdens het seizoen van 2021 wist hij de Formule 1 naar een hoger niveau te tillen, toen hij in een waanzinnige titelstrijd verwikkeld raakte met Lewis Hamilton. Verstappen hoopt echter niet dat deze strijd ooit verfilmd gaat worden. Ook een film over zijn leven ziet hij niet zitten.

Het vernieuwde Albert Park in Melbourne, het circuit waar we komend weekend gaan racen, lijkt maar liefst over vier DRS-zones te beschikken. Het wordt dus oppassen geblazen en er lijkt een hoop inhaalactie voor de boeg te liggen.

Montage door: Ronan Postulart

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DeWalt D240001 Legstand for D24000 Tile Saw | Toolden

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Anti-inflammatory treatment efficacy in depressive disorder. | NDT

Registration and Protocol

This review was registered at PROSPERO under the registration number CRD42022296596 ( A protocol was prepared in advance of conducting the study.

This work is part of a Master’s thesis of the Master’s Program in Clinical Research, Dresden International University, Dresden, Germany.

Author Contributions

All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

TS received grants from the German Federal Ministry of Health and Kurt Goldstein Institut that were not related to this study. TS received royalties from AstraZeneca for consulting and from Dresden International University for serving as program director and lecturer of the Master’s Program in Clinical Research. TS is editorial board member at Neuropsychiatric Disease and Treatment. BI reports financial interest in NOVA discovery and Biomind that were not related to this study. BI serves as program director and lecturer for the Master’s Program in Clinical Research at Dresden International University. MSS, GAH, and AFA declare no potential conflicts of interest.

1. GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the global burden of disease study 2019. Lancet. 2020;396(10258):1204–1222. doi:10.1016/S0140-6736(20)30925-9

2. Bauer M, Monz BU, Montejo AL, et al. Prescribing patterns of antidepressants in Europe: results from the Factors Influencing Depression Endpoints Research (FINDER) study. Eur Psychiatry. 2008;23(1):66–73. doi:10.1016/j.eurpsy.2007.11.001

3. Chee K-Y, Tripathi A, Avasthi A, et al. International study on antidepressant prescription pattern at 40 major psychiatric institutions and hospitals in Asia: a 10-year comparison study. Asia Pac Psychiatry. 2015;7(4):366–374. doi:10.1111/appy.12176

4. Treviño LA, Ruble MW, Treviño K, Weinstein LM, Gresky DP. Antidepressant medication prescribing practices for treatment of major depressive disorder. Psychiatr Serv. 2017;68(2):199–202. doi:10.1176/

5. Hardeveld F, Spijker J, De Graaf R, Nolen WA, Beekman AT. Prevalence and predictors of recurrence of major depressive disorder in the adult population. Acta Psychiatr Scand. 2010;122(3):184–191. doi:10.1111/j.1600-0447.2009.01519.x

6. Hardeveld F, Spijker J, De Graaf R, Nolen WA, Beekman ATF. Recurrence of major depressive disorder and its predictors in the general population: results from The Netherlands Mental Health Survey and Incidence Study (NEMESIS). Psychol Med. 2013;43(1):39–48. doi:10.1017/S0033291712002395

7. Mahlich J, Tsukazawa S, Wiegand F. Estimating prevalence and healthcare utilization for treatment-resistant depression in japan: a retrospective claims database study. Drugs Real World Outcomes. 2018;5(1):35–43. doi:10.1007/s40801-017-0126-5

8. Coppen A, Brooksbank BWL, Peet M. Tryptophan concentration in the cerebrospinal fluid of depressive patients. Lancet. 1972;299(7765):1393. doi:10.1016/S0140-6736(72

9. McClure DJ. The role of dopamine in depression. Can Psychiatr Assoc J. 1973;18(4):309012.

10. Schildkraut JJ. The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiatry. 1965;122(5):509–522. doi:10.1176/ajp.122.5.509

11. Köhler CA, Freitas TH, Maes M, et al. Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies. Acta Psychiatr Scand. 2017;135(5):373–387. doi:10.1111/acps.12698

12. Osimo EF, Pillinger T, Rodriguez IM, Khandaker GM, Pariante CM, Howes OD. Inflammatory markers in depression: a meta-analysis of mean differences and variability in 5166 patients and 5083 controls. Brain Behav Immun. 2020;87:901–909. doi:10.1016/j.bbi.2020.02.010

13. Myint AM. Kynurenines: from the perspective of major psychiatric disorders. FEBS J. 2012;279(8):1375–1385. doi:10.1111/j.1742-4658.2012.08551.x

14. Arteaga-Henriquez G, Burger B, Weidinger E, et al. Activation and deactivation steps in the tryptophan breakdown pathway in major depressive disorder: a link to the monocyte inflammatory state of patients. Prog Neuropsychopharmacol Biol Psychiatry. 2021;107:110226. doi:10.1016/j.pnpbp.2020.110226

15. Grosse L, Carvalho LA, Birkenhager TK, et al. Circulating cytotoxic T cells and natural killer cells as potential predictors for antidepressant response in melancholic depression. Restoration of T regulatory cell populations after antidepressant therapy. Psychopharmacology. 2016;233:1679–1688. doi:10.1007/s00213-015-3943-9

16. Grosse L, Hoogenboezem T, Ambrée O, et al. Deficiencies of the T and natural killer cell system in major depressive disorder. T regulatory cell defects are associated with inflammatory monocyte activation. Brain Behav Immun. 2016;54:38–44. doi:10.1016/j.bbi.2015.12.003

17. Schiweck C, Valles-Colomer M, Arolt V, et al. Depression and suicidality: a link to premature T helper cell aging and increased Th17 cells. Brain Behav Immun. 2020;87:603–609. doi:10.1016/j.bbi.2020.02.005

18. Simon MS, Schiweck C, Arteaga-Henríquez G, et al. Monocyte mitochondrial dysfunction, inflammaging, and inflammatory pyroptosis in major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2021;111:110391. doi:10.1016/j.pnpbp.2021.110391

19. Arteaga-Henríquez G, Simon MS, Burger B, et al. Low-grade inflammation as a predictor of antidepressant and anti-inflammatory therapy response in MDD patients: a systematic review of the literature in combination with an analysis of experimental data collected in the EU-moodinflame consortium. Front Psychiatry. 2019;10:458. doi:10.3389/fpsyt.2019.00458

20. Simon MS, Burger B, Weidinger E, et al. Efficacy of sertraline plus placebo or add-on celecoxib in major depressive disorder: macrophage migration inhibitory factor as a promising biomarker for remission after sertraline – results from a randomized controlled clinical trial. Front Psychiatry. 2021;12:615261. doi:10.3389/fpsyt.2021.615261

21. Strawbridge R, Arnone D, Danese A, Papadopoulos A, Herane Vives A, Cleare AJ. Inflammation and clinical response to treatment in depression: a meta-analysis. Eur Neuropsychopharmacol. 2015;25(10):1532–1543. doi:10.1016/j.euroneuro.2015.06.007

22. Freeman MP, Davis M, Sinha P, Wisner KL, Hibbeln JR, Gelenberg AJ. Omega-3 fatty acids and supportive psychotherapy for perinatal depression: a randomized placebo-controlled study. J Affect Disord. 2008;110(1–2):142–148. doi:10.1016/j.jad.2007.12.228

23. Müller N, Schwarz MJ, Dehning S, et al. The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine. Mol Psychiatry. 2006;11(7):680–684. doi:10.1038/

24. Ghlichloo I, Gerriets V. Nonsteroidal anti-inflammatory drugs (NSAIDs). In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022.

25. Billmeier U, Dieterich W, Neurath MF, Atreya R. Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases. World J Gastroenterol. 2016;22(42):9300–9313. doi:10.3748/wjg.v22.i42.9300

26. Ershad M, Naji A, Vearrier D. N acetylcysteine. In: StatPearls. Treasure Island (FL): StatPearls Publishing;; 2022.

27. Pedre B, Barayeu U, Ezeriņa D, Dick TP. The mechanism of action of N-acetylcysteine (NAC): the emerging role of H2S and sulfane sulfur species. Pharmacol Ther. 2021;228:107916. doi:10.1016/j.pharmthera.2021.107916

28. Garrido-Mesa N, Zarzuelo A, Gálvez J. Minocycline: far beyond an antibiotic. Br J Pharmacol. 2013;169(2):337–352. doi:10.1111/bph.12139

29. Nazarian S, Akhondi H. Minocycline. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022.

30. Krupa K, Fritz K, Parmar M. Omega-3 fatty acids. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022.

31. Raison CL, Rutherford RE, Woolwine BJ, et al. A randomized controlled trial of the tumor necrosis factor-alpha antagonist infliximab in treatment resistant depression: role of baseline inflammatory biomarkers. JAMA Psychiatry. 2013;70(1):31–41. doi:10.1001/2013.jamapsychiatry.4

32. Hasebe K, Gray L, Bortolasci C, et al. Adjunctive N-acetylcysteine in depression: exploration of interleukin-6, C-reactive protein and brain-derived neurotrophic factor. Acta Neuropsychiatr. 2017;29(6):337–346. doi:10.1017/neu.2017.2

33. Musil R, Schwarz MJ, Riedel M, et al. Elevated macrophage migration inhibitory factor and decreased transforming growth factor-beta levels in major depression — no influence of celecoxib treatment. J Affect Disord. 2011;134(1–3):217–225. doi:10.1016/j.jad.2011.05.047

34. Nettis MA, Lombardo G, Hastings C, et al. Augmentation therapy with minocycline in treatment-resistant depression patients with low-grade peripheral inflammation: results from a double-blind randomised clinical trial. Neuropsychopharmacology. 2021;46(5):939–948. doi:10.1038/s41386-020-00948-6

35. Husain MI, Chaudhry IB, Husain N, et al. Minocycline as an adjunct for treatment-resistant depressive symptoms: a pilot randomised placebo-controlled trial. J Psychopharmacol. 2017;31(9):1166–1175. doi:10.1177/0269881117724352

36. Su K-P, Huang S-Y, Chiu T-H, et al. Omega-3 fatty acids for major depressive disorder during pregnancy: results from a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2008;69(4):644–651. doi:10.4088/jcp.v69n0418

37. Baune BT, Sampson E, Louise J, et al. No evidence for clinical efficacy of adjunctive celecoxib with vortioxetine in the treatment of depression: a 6-week double-blind placebo controlled randomized trial. Eur Neuropsychopharmacol. 2021;53:34–46. doi:10.1016/j.euroneuro.2021.07.092

38. Mischoulon D, Nierenberg AA, Schettler PJ, et al. A double-blind, randomized controlled clinical trial comparing eicosapentaenoic acid versus docosahexaenoic acid for depression. J Clin Psychiatry. 2015;76(1):54–61. doi:10.4088/JCP.14m08986

39. Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. doi:10.1136/bmj.n71

40. Higgins JPT, Thomas J, Chandler J, et al., eds. Cochrane Handbook for Systematic Reviews of Interventions. 2nd ed. Chichester (UK): John Wiley & Sons; 2019.

41. Kung J, Chiappelli F, Cajulis OO, et al. From systematic reviews to clinical recommendations for evidence-based health care: validation of Revised Assessment of Multiple Systematic Reviews (R-AMSTAR) for grading of clinical relevance. Open Dent J. 2010;4:84–91. doi:10.2174/1874210601004020084

42. PEROSH OSH Evidence Group. PEROSH – OSH evidence. Clearinghouse of systematic reviews. METHODS; 2014. Available from: Accessed February 3, 2022.

43. Rosenblat JD, McIntyre RS. Efficacy and tolerability of minocycline for depression: a systematic review and meta-analysis of clinical trials. J Affect Disord. 2018;227:219–225. doi:10.1016/j.jad.2017.10.042

44. Zheng W, Zhu X-M, Zhang Q-E, et al. Adjunctive minocycline for major mental disorders: a systematic review. J Psychopharmacol. 2019;33(10):1215–1226. doi:10.1177/0269881119858286

45. Köhler-Forsberg O, Lydholm CN, Hjorthøj C, Nordentoft M, Mors O, Benros ME. Efficacy of anti-inflammatory treatment on major depressive disorder or depressive symptoms: meta-analysis of clinical trials. Acta Psychiatr Scand. 2019;139(5):404–419. doi:10.1111/acps.13016

46. Bai S, Guo W, Feng Y, et al. Efficacy and safety of anti-inflammatory agents for the treatment of major depressive disorder: a systematic review and meta-analysis of randomised controlled trials. J Neurol Neurosurg Psychiatry. 2020;91(1):21–32. doi:10.1136/jnnp-2019-320912

47. Hang X, Zhang Y, Li J, et al. Comparative efficacy and acceptability of anti-inflammatory agents on major depressive disorder: a network meta-analysis. Front Pharmacol. 2021;12:691200. doi:10.3389/fphar.2021.691200

48. Faridhosseini F, Sadeghi R, Farid L, Pourgholami M. Celecoxib: a new augmentation strategy for depressive mood episodes. A systematic review and meta-analysis of randomized placebo-controlled trials. Hum Psychopharmacol. 2014;29(3):216–223. doi:10.1002/hup.2401

49. Na KS, Lee KJ, Lee JS, Cho YS, Jung HY. Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: a meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2014;48:79–85. doi:10.1016/j.pnpbp.2013.09.006

50. Na KS, Lee KJ, Lee JS, Cho YS, Jung HY. Corrigendum to “Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: a meta-analysis” [Prog Neuropsychopharmacol Biol Psychiatry 48 (3 January 2014) 79–85]. Prog Neuropsychopharmacol Biol Psychiatry. 2016;66:136. doi:10.1016/j.pnpbp.2015.11.011

51. Köhler O, Benros ME, Nordentoft M, et al. Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: a systematic review and meta-analysis of randomized clinical trials. JAMA Psychiatry. 2014;71(12):1381–1391. doi:10.1001/jamapsychiatry.2014.1611

52. Yuan Z, Chen Z, Xue M, Zhang J, Leng L. Application of antidepressants in depression: a systematic review and meta-analysis. J Clin Neurosci. 2020;80:169–181. doi:10.1016/j.jocn.2020.08.013

53. Martins JG, Bentsen H, Puri BK. Eicosapentaenoic acid appears to be the key omega-3 fatty acid component associated with efficacy in major depressive disorder: a critique of Bloch and Hannestad and updated meta-analysis. Mol Psychiatry. 2012;17(12):1144–1167. doi:10.1038/mp.2012.25

54. Lin P-Y, Mischoulon D, Freeman MP, et al. Are omega-3 fatty acids antidepressants or just mood-improving agents? The effect depends upon diagnosis, supplement preparation, and severity of depression. Mol Psychiatry. 2012;17(12):1161–1167. doi:10.1038/mp.2012.111

55. Grosso G, Pajak A, Marventano S, et al. Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials. PLoS One. 2014;9(5):e96905. doi:10.1371/journal.pone.0096905

56. Appleton KM, Sallis HM, Perry R, Ness AR, Churchill R. Omega-3 fatty acids for depression in adults. Cochrane Database Syst Rev. 2015;11:CD004692. doi:10.1002/14651858.CD004692.pub4

57. Mocking RJT, Harmsen I, Assies J, Koeter MWJ, Ruhé HG, Schene AH. Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major depressive disorder. Transl Psychiatry. 2016;6(3):e756. doi:10.1038/tp.2016.29

58. Sarris J, Murphy J, Mischoulon D, et al. Adjunctive nutraceuticals for depression: a systematic review and meta-analyses. Am J Psychiatry. 2016;173(6):575–587. doi:10.1176/appi.ajp.2016.15091228

59. Wei-Hong L, Cheng-Gui Z, Peng-Fei G, Heng L, Jian-Fang Y. Omega-3 fatty acids as monotherapy in treating depression in pregnant women: a meta-analysis of randomized controlled trials. Iran J Pharm Res. 2017;16(4):1593–1599.

60. Schefft C, Kilarski LL, Bschor T, Köhler S. Efficacy of adding nutritional supplements in unipolar depression: a systematic review and meta-analysis. Eur Neuropsychopharmacol. 2017;27(11):1090–1109. doi:10.1016/j.euroneuro.2017.07.004

61. Luo X-D, Feng J-S, Yang Z, et al. High-dose omega-3 polyunsaturated fatty acid supplementation might be more superior than low-dose for major depressive disorder in early therapy period: a network meta-analysis. BMC Psychiatry. 2020;20(1):248. doi:10.1186/s12888-020-02656-3

62. Jeremiah OJ, Cousins G, Boland F, Kirby BP, Ryan BK. Evaluation of the effect of insulin sensitivity-enhancing lifestyle- and dietary-related adjuncts on antidepressant treatment response: a systematic review and meta-analysis. Heliyon. 2020;6(9):e04845. doi:10.1016/j.heliyon.2020.e04845

63. Chambergo-Michilot D, Brañez-Condorena A, Falvy-Bockos I, Pacheco-Mendoza J, Benites-Zapata VA. Efficacy of omega-3 supplementation on sertraline continuous therapy to reduce depression or anxiety symptoms: a systematic review and meta-analysis. Psychiatry Res. 2021;296:113652. doi:10.1016/j.psychres.2020.113652

64. Lin P-Y, Su K-P. A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids. J Clin Psychiatry. 2020;81(5):19r13106. doi:10.4088/JCP.19r13106

65. Kraguljac NV, Montori VM, Pavuluri M, Chai HS, Wilson BS, Unal SS. Efficacy of omega-3 fatty acids in mood disorders – a systematic review and metaanalysis. Psychopharmacol Bull. 2009;42(3):39–54.

66. Marins JG. EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials. J Am Coll Nutr. 2009;28(5):525–542. doi:10.1080/07315724.2009.10719785

67. Sublette ME, Ellis SP, Geant AL, Mann JJ. Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression. J Clin Psychiatry. 2011;72(12):1577–1584. doi:10.4088/JCP.10m06634

68. Bloch MH, Hannestad J. Omega-3 fatty acids for the treatment of depression: systematic review and meta-analysis. Mol Psychiatry. 2012;17(12):127212–127282. doi:10.1038/mp.2011.100

69. Yang R-J, Han D, Qiao Z-X, Tian X, Qi D, Qiu X-H. Combined application of eicosapentaenoic acid and docosahexaenoic acid on depression in women: a meta-analysis of double-blind randomized controlled trials. Neuropsychiatr Dis Treat. 2015;11:2055–2061. doi:10.2147/NDT.S86581

70. Fernandez BS, Dean OM, Dodd S, Malhi GS, Berk M. N-acetylcysteine in depressive symptoms and functionality: a systematic review and meta-analysis. J Clin Psychiatry. 2016;77(4):e457–e466. doi:10.4088/JCP.15r09984

71. Hallahan B, Ryan T, Hibbeln JR, et al. Efficacy of omega-3 highly unsaturated fatty acids in the treatment of depression. Br J Psychiatry. 2016;209(3):192–201. doi:10.1192/bjp.bp.114.160242

72. Husain MI, Strawbridge R, Stokes PR, Young AH. Anti-inflammatory treatments for mood disorders: systematic review and meta-analysis. J Psychopharmacol. 2017;31(9):1137–1148. doi:10.1177/0269881117725711

73. Bae J-H, Kim G. Systematic review and meta-analysis of omega-3-fatty acids in elderly patients with depression. Nutr Res. 2018;50:1–9. doi:10.1016/j.nutres.2017.10.013

74. Bai Z-G, Bo A, Wu S-J, Gai Q-Y, Chi I. Omega-3 polyunsaturated fatty acids and reduction of depressive symptoms in older adults: a systematic review and meta-analysis. J Affect Disord. 2018;241:241–248. doi:10.1016/j.jad.2018.07.057

75. Kappelmann N, Lewis G, Dantzer R, Jones PB, Khandaker GM. Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions. Mol Psychiatry. 2018;23(2):335–343. doi:10.1038/mp.2016.167

76. Liao Y, Xie B, Zhang H, et al. Efficacy of omega-3 PUFAs in depression: a meta-analysis. Transl Psychiatry. 2019;9(1):190. doi:10.1038/s41398-019-0515-5

77. Bavaresco DV, Uggioni MLR, Ferraz SD, et al. Efficacy of infliximab in treatment-resistant depression: a systematic review and meta-analysis. Pharmacol Biochem Behav. 2020;188:172838. doi:10.1016/j.pbb.2019.172838

78. Cai DB, Zheng W, Zhang QE, et al. Minocycline for depressive symptoms: a meta-analysis of randomized, double-blinded, placebo-controlled trials. Psychiatr Q. 2020;91(2):451–461. doi:10.1007/s11126-019-09707-3

79. Kishi T, Miyake N, Okuya M, Sakuma K, Iwata N. N-acetylcysteine as an adjunctive treatment for bipolar depression and major depressive disorder: a systematic review and meta-analysis of double-blind, randomized placebo-controlled trials. Psychopharmacology. 2020;237(11):3481–3487. doi:10.1007/s00213-020-05629-2

80. Mocking RJT, Steijn K, Roos C, et al. Omega-3 fatty acid supplementation for perinatal depression: a meta-analysis. J Clin Psychiatry. 2020;81(5):19r13106. doi:10.4088/JCP.19r13106

81. Zhang MM, Zou Y, Li SM, et al. The efficacy and safety of omega-3 fatty acids on depressive symptoms in perinatal women: a meta-analysis of randomized placebo-controlled trials. Transl Psychiatry. 2020;10(1):193. doi:10.1038/s41398-020-00886-3

82. Deane KHO, Jimoh OF, Biswas P, et al. Omega-3 and polyunsaturated fat for prevention of depression and anxiety symptoms: systematic review and meta-analysis of randomised trials. Br J Psychiatry. 2021;218(3):135–142. doi:10.1192/bjp.2019.234

83. Lin PY, Huang SY, Su KP. A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression. Biol Psychiatry. 2010;68(2):140–147. doi:10.1016/j.biopsych.2010.03.018

84. Lin PY, Chang CH, Chong MF, Chen H, Su KP. Polyunsaturated fatty acids in perinatal depression: a systematic review and meta-analysis. Biol Psychiatry. 2017;82(8):560–569. doi:10.1016/j.biopsych.2017.02.1182

85. Yang Y, Kim Y, Je Y. Fish consumption and risk of depression: epidemiological evidence from prospective studies. Asia Pac Psychiatry. 2018;10(4):e12335. doi:10.1111/appy.12335

86. Tolkien K, Bradburn S, Murgatroyd C. An anti-inflammatory diet as a potential intervention for depressive disorders: a systematic review and meta-analysis. Clin Nutr. 2019;38(5):2045–2052. doi:10.1016/j.clnu.2018.11.007

87. Farooq S, Singh SP, Burke D, Naeem F, Ayub M. Pharmacological interventions for prevention of depression in high risk conditions: systematic review and meta-analysis. J Affect Disord. 2020;269:58–69. doi:10.1016/j.jad.2020.03.024

88. Asher GN, Gartlehner G, Gaynes BN, et al. Comparative benefits and harms of complementary and alternative medicine therapies for initial treatment of major depressive disorder: systematic review and meta-analysis. J Altern Complement Med. 2017;23(12):907–919. doi:10.1089/acm.2016.0261

89. Freeman MP, Mischoulon D, Tedeschini E, et al. Complementary and alternative medicine for major depressive disorder: a meta-analysis of patient characteristics, placebo-response rates, and treatment outcomes relative to standard antidepressants. J Clin Psychiatry. 2010;71(6):682–688. doi:10.4088/JCP.10r05976blu

90. Xu Y, Zeng L, Zou K, et al. Role of dietary factors in the prevention and treatment for depression: an umbrella review of meta-analyses of prospective studies. Transl Psychiatry. 2021;11(1):478. doi:10.1038/s41398-021-01590-6

91. Köhler O, Benros M, Nordentoft M, Mors O, Krogh J. Effect of anti-inflammatory treatment on depression and side effects: a systematic review and meta-analysis of randomized clinical trials. Pharmacoepidemiol Drug Saf. 2014;23(Suppl 1):252–253.

92. Köhler O, Benros M, Nordentoft M, Mors P, Krogh J. Effect of anti-inflammatory treatment on depression, depressive symptoms and side effects: a systematic review and meta-analysis of randomized clinical trials. Eur Psychiatry. 2015;30(Suppl 1):0342. doi:10.1016/S0924-9338(15)30268-6

93. Benros M. Immune-related risk factors for schizophrenia and depression in Danish epidemiological studies and meta-analysis of anti-inflammatory treatment for depression. Early Interv Psychiatry. 2016;10(Suppl 1):27.

94. Kim H-B, Kim J-S, Jung J-G. The association between aspirin use and depression: a systematic review and meta-analysis of observational studies. Pharmacoepidemiol Drug Saf. 2020;29(6):613–622. doi:10.1002/pds.5011

95. Suradom C, Suttajit S, Oon-Arom A, Maneeton B, Srisurapanont M. Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation for prevention and treatment of perinatal depression: a systematic review and meta-analysis of randomized-controlled trials. Nord J Psychiatry. 2021;75(4):239–246. doi:10.1080/08039488.2020.1843710

96. Reis DJ, Casteen EJ, Ilardi SS. The antidepressant impact of minocycline in rodents: a systematic review and meta-analysis. Sci Rep. 2019;9(1):261. doi:10.1038/s41598-018-36507-9

97. Zheng W, Zhang QE, Cai DB, et al. N-acetylcysteine for major mental disorders: a systematic review and meta-analysis of randomized controlled trials. Acta Psychiatr Scand. 2018;137(5):391–400. doi:10.1111/acps.12862

98. Emadi-Kouchak H, Mohammadinejad P, Asadollahi-Amin A, et al. Therapeutic effects of minocycline on mild-to-moderate depression in HIV patients: a double-blind, placebo-controlled, randomized trial. Int Clin Psychopharmacol. 2016;31(1):20–26. doi:10.1097/YIC.0000000000000098

99. Dean OM, Kanchanatawan B, Ashton M, et al. Adjunctive minocycline treatment for major depressive disorder: a proof of concept trial. Aust N Z J Psychiatry. 2017;51(8):829–840. doi:10.1177/0004867417709357

100. Akhondzadeh S, Jafari S, Raisi F, et al. Clinical trial of ad- junctive celecoxib treatment in patients with major depression: a double blind and placebo controlled trial. Depress Anxiety. 2009;26(7):607–611. doi:10.1002/da.20589

101. Hashemian F, Majd M, Hosseini SM, Sharifi A, Panahi MVS, Bigdeli O. A randomized, double-blind, placebo-controlled trial of celecoxib augmentation of sertraline in the treatment of a drug-naive women with major depression. Klin Psikofarmakol B. 2011;21:S183–S184.

102. Abbasi SH, Hosseini F, Modabbernia A, Ashrafi M, Akhondzadeh S. Effect of celecoxib add-on treatment on symptoms and serum IL-6 concentrations in patients with major depressive disorder: randomized double-blind placebo-controlled study. J Affect Disord. 2012;141(2–3):308–314. doi:10.1016/j.jad.2012.03.033

103. Majd M, Hashemian F, Hosseini SM, Vahdat Shariatpanahi M, Sharifi A. A randomized, double-blind, placebo-controlled trial of celecoxib augmentation of sertraline in treatment of drug-naive depressed women: a pilot study. Iran J Pharm Res. 2015;14(3):891–899.

104. Nemets B, Stahl Z, Belmaker RH. Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. Am J Psychiatry. 2002;159(3):477–479. doi:10.1176/appi.ajp.159.3.477

105. Peet M, Horrobin DF. A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs. Arch Gen Psychiatry. 2002;59(10):913–919. doi:10.1001/archpsyc.59.10.913

106. Marangell LB, Martinez JM, Zboyan HA, Kertz B, Kim HF, Puryear LJ. A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. Am J Psychiatry. 2003;160(5):996–998. doi:10.1176/appi.ajp.160.5.996

107. Su KP, Huang SY, Chiu CC, Shen WW. Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial. Eur Neuropsychopharmacol. 2003;13(4):267–271. doi:10.1016/s0924-977x(03)00032-4

108. Silvers KM, Woolley CC, Hamilton FC, Watts PM, Watson RA. Randomised double-blind placebo-controlled trial of fish oil in the treatment of depression. Prostaglandins Leukot Essent Fatty Acids. 2005;72(3):211–218. doi:10.1016/j.plefa.2004.11.004

109. Grenyer BF, Crowe T, Meyer B, et al. Fish oil supplementation in the treatment of major depression: a randomised double-blind placebo-controlled trial. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(7):1393–1396. doi:10.1016/j.pnpbp.2007.06.004

110. Jazayeri S, Tehrani-Doost M, Keshavarz SA, et al. Comparison of therapeutic effects of omega-3 fatty acid eicosapentaenoic acid and fluoxetine, separately and in combination, in major depressive disorder. Aust N Z J Psychiatry. 2008;42(3):192–198. doi:10.1080/00048670701827275

111. Rees AM, Austin MP, Parker GB. Omega-3 fatty acids as a treatment for perinatal depression: randomized double-blind placebo-controlled trial. Aust N Z J Psychiatry. 2008;42(3):199–205. doi:10.1080/00048670701827267

112. da Silva TM, Munhoz RP, Alvarez C, et al. Depression in Parkinson’s disease: a double-blind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation. J Affect Disord. 2008;111(2–3):351–359. doi:10.1016/j.jad.2008.03.008

113. Carney RM, Freedland KE, Rubin EH, Rich MW, Steinmeyer BC, Harris WS. Omega-3 augmentation of sertraline in treatment of depression in patients with coronary heart disease: a randomized controlled trial. JAMA. 2009;302(15):1651–1657. doi:10.1001/jama.2009.1487

114. Lucas M, Asselin G, Merette C, Poulin MJ, Dodin S. Ethyleicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trial. Am J Clin Nutr. 2009;89:641–651. doi:10.3945/ajcn.2008.26749

115. Mischoulon D, Papakostas GI, Dording CM, et al. A double-blind, randomized controlled trial of ethyl-eicosapentaenoate for major depressive disorder. J Clin Psychiatry. 2009;70(12):1636–1644. doi:10.4088/JCP.08m04603

116. Bot M, Pouwer F, Assies J, et al. Eicosapentaenoic acid as an add-on to antidepressant medication for co-morbid major depression in patients with diabetes mellitus: a randomized, double-blind placebo-controlled study. J Affect Disord. 2010;126(1–2):282–286. doi:10.1016/j.jad.2010.04.008

117. Rondanelli M, Giacosa A, Opizzi A, et al. Effect of omega-3 fatty acids supplementation on depressive symptoms and on health-related quality of life in the treatment of elderly women with depression: a double-blind, placebo-controlled, randomized clinical trial. J Am Coll Nutr. 2010;29(1):55–64. doi:10.1080/07315724.2010.10719817

118. Gonzalez A, Mata S, Sanchez P, et al. Omega-3 fatty acids as adjunctive of antidepressant therapy and its effects on brain-derived neurotrophic factor in serum, monocytes and lymphocytes. Arch Venez Farmacol Ter. 2011;30(4):72–78.

119. Lespérance F, Frasure-Smith N, St-André E, Turecki G, Lespérance P, Wisniewski SR. The efficacy of omega-3 supplementation for major depression: a randomized controlled trial. J Clin Psychiatry. 2011;72(8):1054–1062. doi:10.4088/JCP.10m05966blu

120. Rondanelli M, Giacosa A, Opizzi A, et al. Long chain omega 3 polyunsaturated fatty acids supplementation in the treatment of elderly depression: effects on depressive symptoms, on phospholipids fatty acids profile and on health-related quality of life. J Nutr Health Aging. 2011;15(1):37–44. doi:10.1007/s12603-011-0011-y

121. Gertsik L, Poland RE, Bresee C, Rapaport MH. Omega-3 fatty acid augmentation of citalopram treatment for patients with major depressive disorder. J Clin Psychopharmacol. 2012;32(1):61–64. doi:10.1097/JCP.0b013e31823f3b5f

122. Rizzo AM, Corsetto PA, Montorfano G, et al. Comparison between the AA/EPA ratio in depressed and non depressed elderly females: omega-3 fatty acid supplementation correlates with improved symptoms but does not change immunological parameters. Nutr J. 2012;11:82. doi:10.1186/1475-2891-11-82

123. Mozaffari-Khosravi H, Yassini-Ardakani M, Karamati M, Shariati-Bafghi SE. Eicosapentaenoic acid versus docosahexaenoic acid in mild-to-moderate depression: a randomized, double-blind, placebo-controlled trial. Eur Neuropsychopharmacol. 2013;23(7):636–644. doi:10.1016/j.euroneuro.2012.08.003

124. Gharekhani A, Khatami MR, Dashti-Khavidaki S, et al. The effect of omega-3 fatty acids on depressive symptoms and inflammatory markers in maintenance hemodialysis patients: a randomized, placebo-controlled clinical trial. Eur J Clin Pharmacol. 2014;70(6):655–665. doi:10.1007/s00228-014-1666-1

125. Park Y, Park YS, Kim SH, Oh DH, Park YC. Supplementation of n-3 polyunsaturated fatty acids for major depressive disorder: a randomized, double-blind, 12-week, placebo-controlled trial in Korea. Ann Nutr Metab. 2015;66(2–3):141–148. doi:10.1159/000377640

126. Rapaport MH, Nierenberg AA, Schettler PJ, et al. Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept study. Mol Psychiatry. 2016;21(1):71–79. doi:10.1038/mp.2015.22

127. Shinto L, Marracci G, Mohr DC, et al. Omega-3 fatty acids for depression in multiple sclerosis: a randomized pilot study. PLoS One. 2016;11(1):e0147195. doi:10.1371/journal.pone.0147195

128. Jahangard L, Sadeghi A, Ahmadpanah M, et al. Influence of adjuvant omega-3-polyunsaturated fatty acids on depression, sleep, and emotion regulation among outpatients with major depressive disorders – results from a double-blind, randomized and placebo-controlled clinical trial. J Psychiatr Res. 2018;107:48–56. doi:10.1016/j.jpsychires.2018.09.016

129. Carney RM, Freedland KE, Rubin EH, Rich MW, Steinmeyer BC, Harris WS. A randomized placebo-controlled trial of omega-3 and sertraline in depressed patients with or at risk for coronary heart disease. J Clin Psychiatry. 2019;80(4):19m12742. doi:10.4088/JCP.19m12742

130. Yang B, Lin L, Bazinet RP, et al. Clinical efficacy and biological regulations of ω-3 PUFA-derived endocannabinoids in major depressive disorder. Psychother Psychosom. 2019;88(4):215–224. doi:10.1159/000501158

131. Coryell WH. Essential fatty acids for major depression. NLM identifier: NCT00256412; 2014 Available from: Accessed July 22, 2014.

132. Raison C, Rutherford RE, Woolwine B, et al. The tumor necrosis factor-alpha antagonist infliximab reduces depressive symptoms in patients with treatment resistant depression and high inflammation. Brain Behav Immun. 2012;26(suppl 1):S49. doi:10.1016/j.bbi.2012.07.200.W

133. Andrade C. Mean difference, Standardized Mean Difference (SMD), and their use in meta-analysis: as simple as it gets. J Clin Psychiatry. 2020;81(5):20f13681. doi:10.4088/JCP.20f13681

134. Lakens D. Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Front Psychol. 2013;4:863. doi:10.3389/fpsyg.2013.00863

135. Alba AC, Alexander PE, Changa J, MacIsaac J, DeFry S, Guyatt GH. High statistical heterogeneity is more frequent in meta-analysis of continuous than binary outcomes. J Clin Epidemiol. 2016;70:129–135. doi:10.1016/j.jclinepi.2015.09.005

136. Russo MW. How to review a meta-analysis. Gastroenterol Hepatol. 2007;3(8):637–642.

137. Andrade C. Anti-inflammatory treatments for depression: perspectives on how to read a meta-analysis critically. J Clin Psychiatry. 2019;80(3):19f12907. doi:10.4088/JCP.19f12907

138. Silverman MN, Sternberg E. Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction. Ann N Y Acad Sci. 2012;1261:55–63. doi:10.1111/j.1749-6632.2012.06633.x

139. Cipriani A, Furukawa TA, Salanti G, et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet. 2018;391(10128):1357–1366. doi:10.1016/S0140-6736(17)32802-7

140. Furukawa TA, Cipriani A, Cowen PJ, Leucht S, Egger M, Salanti G. Optimal dose of selective serotonin reuptake inhibitors, venlafaxine, and mirtazapine in major depression: a systematic review and dose-response meta-analysis. Lancet Psychiatry. 2019;6(7):601–609. doi:10.1016/S2215-0366(19)30217-2

141. Guo X, McCutcheon RA, Pillinger T, et al. The magnitude and heterogeneity of antidepressant response in depression: a meta-analysis of over 45,000 patients. J Affect Disord. 2020;276:991–1000. doi:10.1016/j.jad.2020.07.102

142. Drevets WC, Wittenberg GM, Bullmore ET, Manji HK. Immune targets for therapeutic development in depression: towards precision medicine. Nat Rev Drug Discov. 2022;21:224–244. doi:10.1038/s41573-021-00368-1

143. Sorgdrager FJH, Naudé PJW, Kema IP, Nollen EA, De Deyn PP. Tryptophan metabolism in inflammaging: from biomarker to therapeutic target. Front Immunol. 2019;10:2565. doi:10.3389/fimmu.2019.02565

144. Berk M, Williams LJ, Jacka FN, et al. So depression is an inflammatory disease, but where does the inflammation come from? BMC Med. 2013;11:200. doi:10.1186/1741-7015-11-200

145. Medina-Rodriguez EM, Lowell JA, Worthen RJ, Syed SA, Beurel E. Involvement of innate and adaptive immune systems alterations in the pathophysiology and treatment of depression. Front Neurosci. 2018;12:547. doi:10.3389/fnins.2018.00547

146. Visentin A, Colombo R, Scotton E, et al. Targeting inflammatory-mitochondrial response in major depression: current evidence and further challenges. Oxid Med Cell Longev. 2020;2020:2972968. doi:10.1155/2020/2972968

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‘Bottles, glass, bullets’: inside the wreckage of Brazil’s failed coup | Brazil | The Guardian

A blue Adolf Hitler moustache had been daubed onto a portrait of the Duke of Caxias, a 19th century prime minister, on the second floor of Brazil’s presidential palace.

The Duke of Caxias in the presidential palace of Brazil.

A multimillion dollar masterpiece by the modernist legend Emiliano Di Cavalcanti was stabbed seven times.

Not even the palace’s press rooms escaped the wrath of thousands of far-right insurrectionists when they stormed the building on Sunday afternoon, as well as the national congress and supreme court.

After smashing their way into Oscar Niemeyer’s breathtaking curved creation, extremists relieved themselves in the press room and defecated in the room for photographers next door.

“The whole place stank of urine and beer,” one palace employee said of the moment officials reentered the building after Sunday’s day of rage to discover scenes of inconceivable depredation.

Di Cavalcanti work that was slashed.

The Guardian toured two of the three ransacked buildings in Brasília on Monday afternoon, 24 hours after the attack by hardcore followers of the former president Jair Bolsonaro.

The Planalto palace and the national congress are both architectural gems at the heart of Niemeyer and urban planner Lúcio Costa’s bold 1950s vision of a new, forward-looking Brazil.

Both now appear to have been hit by a natural disaster, their outer windows smashed to smithereens by rampaging Bolsonaristas desperate to overturn the result of October’s election, which their radical leader lost to his left-wing rival Luiz Inácio Lula da Silva.

At the senate museum, plaques still read: “Please do not touch the artwork.” But rioters ignored those as they swept into the exhibit room and began wrecking hundreds of years of Brazilian art and political history.

A knife had been taken to portraits of former senate presidents Renan Calheiros and José Sarney. A copy of the Brazilian constitution had been slammed through the top of a display case and was now framed by shards of broken glass.

Outside, the right-wing rebels had left artwork of their own; crudely scrawled graffiti demanding a pro-Bolsonaro military coup and an end to the communist threat they are convinced has taken hold of Brazil with Lula’s election win.

“Scumbags,” one cleaning lady fumed of the putschists as she and dozens of others swept congress’s glass-covered blue and lime green carpets and engineers checked for structural damage.

Workers replaced a smashed mirror where a vandalized painting hung in Brasília after Bolsonaro supporters stormed congress.

Nearby, the entrance to the offices of the senate’s current president, Rodrigo Pacheco, looked like a bank that had been targeted by ram-raiders. A Chinese X-ray machine lay on its side; chunks of glass covered the floor; internet cables dangled from the ceiling like vines; two shattered desktop computers lay on a table, their motherboards spilling out from inside.

At the presidential palace, there were similar scenes of gratuitous and often infantile destruction.

Cobblestones had been ripped up from the entrance, where just one week earlier hundreds of guests had celebrated Lula’s inauguration and what they had hoped would be a progressive new era of reconciliation and environmental protection after four years of division and hate.

Cleaners waded through the ornamental water features beneath the palace’s marble ramp using nets to fish out the detritus of the previous day’s chaos.

“Bottles, glass, [rubber] bullets,” one of the workers said of the objects being retrieved from the water mirror as the clean-up continued.

The rioters made it into the inner sanctum of what should be one of Brazil’s most secure addresses, leaving a bizarre trail of destruction and fury in their wake and many questions over how such a politically-sensitive building could have been left so exposed.

The mob failed to access the offices of president Lula but other rooms were looted and smashed. A felt-tip pen was used to scrawl curly lines along the ceiling of the corridor occupied by members of the Institutional Security Bureau, which is responsible for the president’s safety. Chairs were hurled from the broken windows and rioters tried to torch a sofa.

One of Lula’s closest aides, Celso Amorim, said his office and that of Brazil’s first lady, Rosângela Lula da Silva, had been vandalized, with the insurgents appearing to trash her workplace with particular relish.

Amorim, who is Brazil’s former defense minister, said he was struggling to fathom how security forces and intelligence agencies had failed to detect or stop the threat. “The resistance only came after the deed had been done – it’s as if it was allowed to happen,” he said.

Journalists were not allowed into the third sacked building, the supreme court, on Monday afternoon as federal police forensic officers picked their way through its wreckage in search of fingerprints, clues and perhaps even booby traps left by the Bolsonaristas. But the white graffiti on the court’s facade spoke to the bedlam that had unfolded inside. “I came, I won,” said one daubed slogan. Another read: “You lost, you prick.”

As the Guardian approached the building, a black-clad member of the bomb disposal unit asked reporters to retreat: the controlled explosion of what he called “a grenade” was being carried out just metres from its entrance.

Minutes later, an ear-splitting bang rang out across the Three Powers Plaza, which Costa and Niemeyer had intended as a symbol of political harmony between Brazil’s executive, judiciary and legislative branches.

“It’s heartbreaking,” said a military policeman who was guarding the court and said several of his colleagues had been injured during the pro-Bolsonaro rampage. “Let us hope that better days lie ahead.”

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