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Max Verstappen heeft de laatste jaren flink aan populariteit gewonnen in de wereld. Met name tijdens het seizoen van 2021 wist hij de Formule 1 naar een hoger niveau te tillen, toen hij in een waanzinnige titelstrijd verwikkeld raakte met Lewis Hamilton. Verstappen hoopt echter niet dat deze strijd ooit verfilmd gaat worden. Ook een film over zijn leven ziet hij niet zitten.

Het vernieuwde Albert Park in Melbourne, het circuit waar we komend weekend gaan racen, lijkt maar liefst over vier DRS-zones te beschikken. Het wordt dus oppassen geblazen en er lijkt een hoop inhaalactie voor de boeg te liggen.

Montage door: Ronan Postulart

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Registration and Protocol

This review was registered at PROSPERO under the registration number CRD42022296596 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=296596). A protocol was prepared in advance of conducting the study.

This work is part of a Master’s thesis of the Master’s Program in Clinical Research, Dresden International University, Dresden, Germany.

Author Contributions

All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

TS received grants from the German Federal Ministry of Health and Kurt Goldstein Institut that were not related to this study. TS received royalties from AstraZeneca for consulting and from Dresden International University for serving as program director and lecturer of the Master’s Program in Clinical Research. TS is editorial board member at Neuropsychiatric Disease and Treatment. BI reports financial interest in NOVA discovery and Biomind that were not related to this study. BI serves as program director and lecturer for the Master’s Program in Clinical Research at Dresden International University. MSS, GAH, and AFA declare no potential conflicts of interest.

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82. Deane KHO, Jimoh OF, Biswas P, et al. Omega-3 and polyunsaturated fat for prevention of depression and anxiety symptoms: systematic review and meta-analysis of randomised trials. Br J Psychiatry. 2021;218(3):135–142. doi:10.1192/bjp.2019.234

83. Lin PY, Huang SY, Su KP. A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression. Biol Psychiatry. 2010;68(2):140–147. doi:10.1016/j.biopsych.2010.03.018

84. Lin PY, Chang CH, Chong MF, Chen H, Su KP. Polyunsaturated fatty acids in perinatal depression: a systematic review and meta-analysis. Biol Psychiatry. 2017;82(8):560–569. doi:10.1016/j.biopsych.2017.02.1182

85. Yang Y, Kim Y, Je Y. Fish consumption and risk of depression: epidemiological evidence from prospective studies. Asia Pac Psychiatry. 2018;10(4):e12335. doi:10.1111/appy.12335

86. Tolkien K, Bradburn S, Murgatroyd C. An anti-inflammatory diet as a potential intervention for depressive disorders: a systematic review and meta-analysis. Clin Nutr. 2019;38(5):2045–2052. doi:10.1016/j.clnu.2018.11.007

87. Farooq S, Singh SP, Burke D, Naeem F, Ayub M. Pharmacological interventions for prevention of depression in high risk conditions: systematic review and meta-analysis. J Affect Disord. 2020;269:58–69. doi:10.1016/j.jad.2020.03.024

88. Asher GN, Gartlehner G, Gaynes BN, et al. Comparative benefits and harms of complementary and alternative medicine therapies for initial treatment of major depressive disorder: systematic review and meta-analysis. J Altern Complement Med. 2017;23(12):907–919. doi:10.1089/acm.2016.0261

89. Freeman MP, Mischoulon D, Tedeschini E, et al. Complementary and alternative medicine for major depressive disorder: a meta-analysis of patient characteristics, placebo-response rates, and treatment outcomes relative to standard antidepressants. J Clin Psychiatry. 2010;71(6):682–688. doi:10.4088/JCP.10r05976blu

90. Xu Y, Zeng L, Zou K, et al. Role of dietary factors in the prevention and treatment for depression: an umbrella review of meta-analyses of prospective studies. Transl Psychiatry. 2021;11(1):478. doi:10.1038/s41398-021-01590-6

91. Köhler O, Benros M, Nordentoft M, Mors O, Krogh J. Effect of anti-inflammatory treatment on depression and side effects: a systematic review and meta-analysis of randomized clinical trials. Pharmacoepidemiol Drug Saf. 2014;23(Suppl 1):252–253.

92. Köhler O, Benros M, Nordentoft M, Mors P, Krogh J. Effect of anti-inflammatory treatment on depression, depressive symptoms and side effects: a systematic review and meta-analysis of randomized clinical trials. Eur Psychiatry. 2015;30(Suppl 1):0342. doi:10.1016/S0924-9338(15)30268-6

93. Benros M. Immune-related risk factors for schizophrenia and depression in Danish epidemiological studies and meta-analysis of anti-inflammatory treatment for depression. Early Interv Psychiatry. 2016;10(Suppl 1):27.

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110. Jazayeri S, Tehrani-Doost M, Keshavarz SA, et al. Comparison of therapeutic effects of omega-3 fatty acid eicosapentaenoic acid and fluoxetine, separately and in combination, in major depressive disorder. Aust N Z J Psychiatry. 2008;42(3):192–198. doi:10.1080/00048670701827275

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112. da Silva TM, Munhoz RP, Alvarez C, et al. Depression in Parkinson’s disease: a double-blind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation. J Affect Disord. 2008;111(2–3):351–359. doi:10.1016/j.jad.2008.03.008

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115. Mischoulon D, Papakostas GI, Dording CM, et al. A double-blind, randomized controlled trial of ethyl-eicosapentaenoate for major depressive disorder. J Clin Psychiatry. 2009;70(12):1636–1644. doi:10.4088/JCP.08m04603

116. Bot M, Pouwer F, Assies J, et al. Eicosapentaenoic acid as an add-on to antidepressant medication for co-morbid major depression in patients with diabetes mellitus: a randomized, double-blind placebo-controlled study. J Affect Disord. 2010;126(1–2):282–286. doi:10.1016/j.jad.2010.04.008

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123. Mozaffari-Khosravi H, Yassini-Ardakani M, Karamati M, Shariati-Bafghi SE. Eicosapentaenoic acid versus docosahexaenoic acid in mild-to-moderate depression: a randomized, double-blind, placebo-controlled trial. Eur Neuropsychopharmacol. 2013;23(7):636–644. doi:10.1016/j.euroneuro.2012.08.003

124. Gharekhani A, Khatami MR, Dashti-Khavidaki S, et al. The effect of omega-3 fatty acids on depressive symptoms and inflammatory markers in maintenance hemodialysis patients: a randomized, placebo-controlled clinical trial. Eur J Clin Pharmacol. 2014;70(6):655–665. doi:10.1007/s00228-014-1666-1

125. Park Y, Park YS, Kim SH, Oh DH, Park YC. Supplementation of n-3 polyunsaturated fatty acids for major depressive disorder: a randomized, double-blind, 12-week, placebo-controlled trial in Korea. Ann Nutr Metab. 2015;66(2–3):141–148. doi:10.1159/000377640

126. Rapaport MH, Nierenberg AA, Schettler PJ, et al. Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept study. Mol Psychiatry. 2016;21(1):71–79. doi:10.1038/mp.2015.22

127. Shinto L, Marracci G, Mohr DC, et al. Omega-3 fatty acids for depression in multiple sclerosis: a randomized pilot study. PLoS One. 2016;11(1):e0147195. doi:10.1371/journal.pone.0147195

128. Jahangard L, Sadeghi A, Ahmadpanah M, et al. Influence of adjuvant omega-3-polyunsaturated fatty acids on depression, sleep, and emotion regulation among outpatients with major depressive disorders – results from a double-blind, randomized and placebo-controlled clinical trial. J Psychiatr Res. 2018;107:48–56. doi:10.1016/j.jpsychires.2018.09.016

129. Carney RM, Freedland KE, Rubin EH, Rich MW, Steinmeyer BC, Harris WS. A randomized placebo-controlled trial of omega-3 and sertraline in depressed patients with or at risk for coronary heart disease. J Clin Psychiatry. 2019;80(4):19m12742. doi:10.4088/JCP.19m12742

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A blue Adolf Hitler moustache had been daubed onto a portrait of the Duke of Caxias, a 19th century prime minister, on the second floor of Brazil’s presidential palace.

A multimillion dollar masterpiece by the modernist legend Emiliano Di Cavalcanti was stabbed seven times.

Not even the palace’s press rooms escaped the wrath of thousands of far-right insurrectionists when they stormed the building on Sunday afternoon, as well as the national congress and supreme court.

After smashing their way into Oscar Niemeyer’s breathtaking curved creation, extremists relieved themselves in the press room and defecated in the room for photographers next door.

“The whole place stank of urine and beer,” one palace employee said of the moment officials reentered the building after Sunday’s day of rage to discover scenes of inconceivable depredation.

The Guardian toured two of the three ransacked buildings in Brasília on Monday afternoon, 24 hours after the attack by hardcore followers of the former president Jair Bolsonaro.

The Planalto palace and the national congress are both architectural gems at the heart of Niemeyer and urban planner Lúcio Costa’s bold 1950s vision of a new, forward-looking Brazil.

Both now appear to have been hit by a natural disaster, their outer windows smashed to smithereens by rampaging Bolsonaristas desperate to overturn the result of October’s election, which their radical leader lost to his left-wing rival Luiz Inácio Lula da Silva.

At the senate museum, plaques still read: “Please do not touch the artwork.” But rioters ignored those as they swept into the exhibit room and began wrecking hundreds of years of Brazilian art and political history.

A knife had been taken to portraits of former senate presidents Renan Calheiros and José Sarney. A copy of the Brazilian constitution had been slammed through the top of a display case and was now framed by shards of broken glass.

Outside, the right-wing rebels had left artwork of their own; crudely scrawled graffiti demanding a pro-Bolsonaro military coup and an end to the communist threat they are convinced has taken hold of Brazil with Lula’s election win.

“Scumbags,” one cleaning lady fumed of the putschists as she and dozens of others swept congress’s glass-covered blue and lime green carpets and engineers checked for structural damage.

Nearby, the entrance to the offices of the senate’s current president, Rodrigo Pacheco, looked like a bank that had been targeted by ram-raiders. A Chinese X-ray machine lay on its side; chunks of glass covered the floor; internet cables dangled from the ceiling like vines; two shattered desktop computers lay on a table, their motherboards spilling out from inside.

At the presidential palace, there were similar scenes of gratuitous and often infantile destruction.

Cobblestones had been ripped up from the entrance, where just one week earlier hundreds of guests had celebrated Lula’s inauguration and what they had hoped would be a progressive new era of reconciliation and environmental protection after four years of division and hate.

Cleaners waded through the ornamental water features beneath the palace’s marble ramp using nets to fish out the detritus of the previous day’s chaos.

“Bottles, glass, [rubber] bullets,” one of the workers said of the objects being retrieved from the water mirror as the clean-up continued.

The rioters made it into the inner sanctum of what should be one of Brazil’s most secure addresses, leaving a bizarre trail of destruction and fury in their wake and many questions over how such a politically-sensitive building could have been left so exposed.

The mob failed to access the offices of president Lula but other rooms were looted and smashed. A felt-tip pen was used to scrawl curly lines along the ceiling of the corridor occupied by members of the Institutional Security Bureau, which is responsible for the president’s safety. Chairs were hurled from the broken windows and rioters tried to torch a sofa.

One of Lula’s closest aides, Celso Amorim, said his office and that of Brazil’s first lady, Rosângela Lula da Silva, had been vandalized, with the insurgents appearing to trash her workplace with particular relish.

Amorim, who is Brazil’s former defense minister, said he was struggling to fathom how security forces and intelligence agencies had failed to detect or stop the threat. “The resistance only came after the deed had been done – it’s as if it was allowed to happen,” he said.

Journalists were not allowed into the third sacked building, the supreme court, on Monday afternoon as federal police forensic officers picked their way through its wreckage in search of fingerprints, clues and perhaps even booby traps left by the Bolsonaristas. But the white graffiti on the court’s facade spoke to the bedlam that had unfolded inside. “I came, I won,” said one daubed slogan. Another read: “You lost, you prick.”

As the Guardian approached the building, a black-clad member of the bomb disposal unit asked reporters to retreat: the controlled explosion of what he called “a grenade” was being carried out just metres from its entrance.

Minutes later, an ear-splitting bang rang out across the Three Powers Plaza, which Costa and Niemeyer had intended as a symbol of political harmony between Brazil’s executive, judiciary and legislative branches.

“It’s heartbreaking,” said a military policeman who was guarding the court and said several of his colleagues had been injured during the pro-Bolsonaro rampage. “Let us hope that better days lie ahead.”